I have a pretty bad toothache. My husband says that I need to see a dentist. However, I have pretty bad dental anxiety. He’s suggesting I get dental sedation. I looked into that and it does look like a good option. The one thing that has me worried is an article I read about a woman in Iowa who died during a dental procedure where the dentist gave her double the recommended dose. Is there a way to ensure that won’t happen?
Carol
Dear Carol,
I am glad you wrote. First, I want to let you know right up front that dental sedation is safe. We’ll go over this particular case in a bit. I just didn’t want you worried about getting the care you need. If you have a bad toothache, there are decent chances that you’re looking at needing emergency dental care. It’s best to call sooner rather than later so that you can have a pain and anxiety free appointment.
I am familiar with the case from Iowa. I even know a dentist who wrote a legal opinion on this case. The dentist, in this case, did not do anything that led to this woman’s death. While the recommended dose of triazolam was 0.5 mg and this patient was given 1.0 mg, there are some important considerations here. First, the patient was 270 pounds, which is twice the weight of a woman who would normally take this medication. That would require a higher dose. When she arrived at the office she showed no signs that the medicine she already had taken was affecting her. Normally, you are very sleepy after taking this medication, but she was lucid and having conversations with the staff, showing no signs that it was even working. If she had too much sedation, she would not be able to converse with them at all. She did have a history of drug abuse as well.
To help you understand how safe this medication is, I’m going to quote the dentist who wrote the legal opinion about it. “Some drugs have a wide safety margin. Triazolam is such a drug. To determine the maximum safe dose, we need to turn to clinical data establishing what is called the LD-50. The LD-50 of a drug is the dose at which 50% of the animals in a clinical trial die. This dose is extremely high for triazolam. Tested on mice, its LD-50 is greater than 1,000 mg/kg (see Halcion data from the FDA). For a 270-pound woman (a little over 120 kg), that would work out to a dose of 120,000 mg. While mice data can’t be extrapolated accurately to humans, it does give us a rough idea of the safety.” You can read his entire post about this case here.
This patient was no where close to a dangerous amount of the medication. In fact, it would be extremely difficult to get that much of the medication.
Don’t let a rare incident, that had other mitigating factors, keep you from getting the care you need. A tooth infection should not be ignored. Otherwise a dental emergency could turn into something life threating once the infection spills out of the tooth.
This blog is brought to you by Lexington, KY Dentist Dr. Fred Arnold.